Lean Body Mass: The benefits of HMB on lean body mass have been demonstrated in over 30 clinical studies involving both young and aging cohorts with diverse backgrounds of physical conditioning. HMB provides powerful support for maintaining muscle mass when combined with an exercise program. By supporting the integrity of muscle fibers and protecting important contractile proteins, HMB helps maintain muscle strength. HMB also directly supports protein synthesis by maintaining healthy growth factor signaling and ribosome activity in muscle cells. Both HMB and alpha lipoic acid support intramuscular antioxidant status and maintain inflammatory balance. Alpha lipoic acid helps maintain muscle mass by supporting reduced glutathione pools and encourages metabolic homeostasis by promoting normal glucose uptake. Well-known for its role in bioenergetics and ATP repletion, creatine activates different pathways to support both aerobic and aerobic exercise adaptations. Specifically, creatine supports healthy gene expression and growth factor activity to promote protein synthesis.