Ribose is a pentose sugar found in all living cells. It is important for maintaining healthy total adenine nucleotide pools and ultimately for the production of adenosine triphosphate (ATP), promoting skeletal and cardiac muscle energy metabolism. Although the body has the ability to manufacture ribose from glucose, it is a slow process which requires glucose-6-phosphate dehydrogenase (G-6-PDH), an enzyme typically in short supply. Supplemental ribose allows the body to bypass this step, rapidly supplying the compounds needed to boost salvage and enhance de novo synthesis. Research indicates that nucleotides decrease after repeated, intense exercise and that they may not be recovered for up to several days, leaving muscle without the ability to refuel energy stores. Ribose also offers powerful, complementary support to creatine by enhancing TAN pools, providing the necessary substrates which creatine can then convert to ATP.